Jingmin Zhao1, Guangde Zhou1, Suxian Zhao1, Huaming Wang2, Peirui Zhang3, Xianzhi Zhou4
1 Department of Pathology, 302 Hospital of PLA, Beijing, China, 2 Department of Radiology, 302 Hospital of PLA,Beijing,China, 3 Department of Hepatobilliary Surgery,302 Hospital of PLA,Beijing,China, 4 Department of Hepatology,302 Hospital of PLA,Beijing,China
Abstract text : The hepatic follicular dendritic cell sarcoma (FDCS) is an exceedingly rare neoplasm. Only 12 cases have been reported to date. Here, we report a case of hepatic FDCS with Epstein-Barr virus expression and chronic hepatitis B virus (HBV) infection. The clinical, radiological, and pathological findings of this case were described. Histologically, the resected tumor showed an arrangement of fascicle of spindle cells with some Reed-Sternberg like giant cells in a background of predominant lymphocyte infiltration. Immunohistochemical studies showed that the tumor cells were positive for CD21, CD35, CD68, Epstein-Barr virus (EBV) latent membrane protein, but were negative for HBV markers. The diagnosis of the tumor could be confirmed based on the histological features and immunohistochemical staining. Although EBV may be involved in the pathogenesis of hepatic FDCS, in this case, we do not have direct evidence that HBV is associated with hepatic FDCS.